L-Proline → HCID 53899108, compound

HRID 1155033Notes

Reaction equation

HRID 1155033 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]([CH:8]=[CH:9][C:10]([OH:12])=O)=[O:7])[C:3]2[CH:13]=[CH:14][CH:15]=[CH:16][C:2]1=2.[NH:17]1[CH2:24][CH2:23][CH2:22][C@H:18]1[C:19]([OH:21])=[O:20]>O1CCCC1>[S:1]1[CH:5]=[C:4]([C:6]([CH:8]=[CH:9][C:10]([N:17]2[CH2:24][CH2:23][CH2:22][C@H:18]2[C:19]([OH:21])=[O:20])=[O:12])=[O:7])[C:3]2[CH:13]=[CH:14][CH:15]=[CH:16][C:2]1=2

Participants

4

Reactant 2

HCID 145742L-ProlineHCID 571183943-(Benzo[b]thien-3-ylcarbonyl)acrylic acid

Product 1

HCID 53899108HCID 53899108, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

As for Example 1, 3-(benzo[b]thien-3-ylcarbonyl)acrylic acid (0.01 mole) is coupled to L-proline (0.01 mole) with N,N'-carbonyldiimidazole in tetrahydrofuran to give 1-[3-(benzo[b]thien-3-ylcarbonyl)acryloyl]-L-proline.

Sources & evidence

ORD record
ord-b8089cb5f41e4bea9be31116a6d1d072
Source dataset
uspto-grants-1981_11
Patent number
US04299769

Reaction notes

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