HCID 178469125, compound → 4-Hydroxy-2-(trifluoromethyl)quinoline-3-carboxylic acid

HRID 1155059Notes

Reaction equation

HRID 1155059 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[C:12]([C:13]([O:15]CC)=[O:14])=[C:11]([OH:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1>CCOCC>[F:20][C:2]([F:1])([F:19])[C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]([OH:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

3

Reactant 1

HCID 178469125HCID 178469125, compound

Product 1

HCID 1785245364-Hydroxy-2-(trifluoromethyl)quinoline-3-carboxylic acidYield 97.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using the procedure of Step E of Example 8, 30 g of the product of Step D were reacted to obtain without ether purification 26.3 g of 2-trifluoromethyl-4-hydroxy-3-quinoline-carboxylic acid melting at 262° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-26d1f82ff02340d5bfcadec49ef05996
Source dataset
uspto-grants-1981_11
Patent number
US04299831

Reaction notes

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