2-Aminothiazole → HCID 178438816, compound

HRID 1155061Notes

Reaction equation

HRID 1155061 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[C:12]([C:13](Cl)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:17]([CH3:19])[CH3:18])[CH:9]=2)[N:4]=1.[NH2:22][C:23]1[S:24][CH:25]=[CH:26][N:27]=1>>[F:1][C:2]([F:21])([F:20])[C:3]1[C:12]([C:13]([NH:22][C:23]2[S:24][CH:25]=[CH:26][N:27]=2)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:17]([CH3:19])[CH3:18])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 178438815HCID 178438815, compound

Product 1

HCID 178438816HCID 178438816, compound

Procedure

Using the procedure of Step F of Example 1, the product of Step F and 10 g of 2-amino-thiazole were reacted to obtain after crystallization from isopropanol 9.64 g of 2-trifluoromethyl-6-isopropyl-4-hydroxy-N-(2-thiazolyl)-3-quinolinecarboxamide melting at 262° C.

Workup

  1. customto obtain
  2. customafter crystallization from isopropanol 9.64 g of 2-trifluoromethyl-6-isopropyl-4-hydroxy-N-(2-thiazolyl)-3-quinolinecarboxamide melting at 262° C.

Sources & evidence

ORD record
ord-62b0e7eda2df42d4a8a1b14898b8cbcb
Source dataset
uspto-grants-1981_11
Patent number
US04299831

Reaction notes

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