2-Aminothiazole → HCID 178487934, compound

HRID 1155062Notes

Reaction equation

HRID 1155062 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[C:12]([C:13](Cl)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:17][CH3:18])[CH:9]=2)[N:4]=1.[NH2:21][C:22]1[S:23][CH:24]=[CH:25][N:26]=1>>[F:1][C:2]([F:20])([F:19])[C:3]1[C:12]([C:13]([NH:21][C:22]2[S:23][CH:24]=[CH:25][N:26]=2)=[O:14])=[C:11]([OH:16])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:17][CH3:18])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 178487933HCID 178487933, compound

Product 1

HCID 178487934HCID 178487934, compound

Procedure

Using the procedure of Step F of Example 1, the product of Step F and 1.05 g of 2-amino-thiazole were reacted to obtain after crystallization from ethanol 1.6 g of 2-trifluoromethyl-6-methoxy-4-hydroxy-N-(2-thiazolyl)-3-quinolinecarboxamide melting at >270° C.

Workup

  1. customto obtain
  2. customafter crystallization from ethanol 1.6 g of 2-trifluoromethyl-6-methoxy-4-hydroxy-N-(2-thiazolyl)-3-quinolinecarboxamide melting at >270° C.

Sources & evidence

ORD record
ord-68b519576bb946b9951475ba44a707f9
Source dataset
uspto-grants-1981_11
Patent number
US04299831

Reaction notes

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