反应详情

A mixture of 4.1 g of 4,5-diamino-pyrimidine dihydrochloride, 7.1 g of 2-methoxy-4-methylmercapto-benzoylchloride, and 50 ml of phosphorus oxychloride was refluxed for three hours. The reaction mixture was evaporated until one-half of the original volume remained, and then the remaining mixture was poured into water. The precipitate that formed was dissolved in boiling ethanol, precipitated by addition of ether, and purified by chromatography on silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1).

1. temperaturewas refluxed for three hours
2. customThe reaction mixture was evaporated until one-half of the original volume
3. additionthe remaining mixture was poured into water
4. customThe precipitate that formed
5. dissolutionwas dissolved
6. customprecipitated by addition of ether
7. custompurified by chromatography on silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1)