Potassium Carbonate → 2-(1,4-BENZODIOXAN-2YL)-METHYLENE-BENZIMIDAZOLE

HRID 1155294Notes

Reaction equation

HRID 1155294 reaction equation
Cl.[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[N:14]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 12761781HCID 12761781, compound

Product 1

HCID 127617802-(1,4-BENZODIOXAN-2YL)-METHYLENE-BENZIMIDAZOLE

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-(1,4-benzodioxan-2-ylmethyl)benzimidazole hydrochloride (1.0 g) suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 2-(1,4-benzodioxan-2-ylmethyl)benzimidazole.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-54f10b772d3b4f11b68bee647f30b9b3
Source dataset
uspto-grants-1981_11
Patent number
US04301171

Reaction notes

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