Dimethylformamide → HCID 86738113, compound

Participants

Reaction Steps

3.93 g (11 mmol) of methyl triphenylphosphonium bromide in 100 ml of absolute dimethyl formamide is treated with 1.01 g of a 50% w/w sodium hydride dispersion in oil (21 mmol) under nitrogen. The mixture is stirred for 1 hour at room temperature, and then treated with 2.59 g of octahydro-4a-(3-hydroxyphenyl)-2-methyl-cis-6(2H)-isoquinolinone. The mixture is stirred for 16 hours at 40°, and partitioned between methylene chloride and aqueous ammonium sulphate. Evaporation of the organic phase and chromatographic purification on silicagel gives the title compound.

Provenance & Evidence