反应详情

3.93 g (11 mmol) of methyl triphenylphosphonium bromide in 100 ml of absolute dimethyl formamide is treated with 1.01 g of a 50% w/w sodium hydride dispersion in oil (21 mmol) under nitrogen. The mixture is stirred for 1 hour at room temperature, and then treated with 2.59 g of octahydro-4a-(3-hydroxyphenyl)-2-methyl-cis-6(2H)-isoquinolinone. The mixture is stirred for 16 hours at 40°, and partitioned between methylene chloride and aqueous ammonium sulphate. Evaporation of the organic phase and chromatographic purification on silicagel gives the title compound.

1. stirringThe mixture is stirred for 16 hours at 40°
2. custompartitioned between methylene chloride and aqueous ammonium sulphate
3. customEvaporation of the organic phase and chromatographic purification on silicagel