Diethylamine → HCID 12784096, compound

HRID 1155380Notes

Reaction equation

HRID 1155380 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])[CH3:2].[CH2:26]([NH:28][CH2:29][CH3:30])[CH3:27]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1[N:28]([CH2:29][CH3:30])[CH2:26][CH3:27])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 12784117HCID 12784117, compound

Product 1

HCID 12784096HCID 12784096, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Two grams (0.0056 mole) of 5-chloro-7,8-dihydro-8-ethyl-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (prepared by the method of Example 3, first paragraph) and 0.82 g. (0.011 mole) of diethylamine were added together in ethanol in an autoclave and heated on a steam bath for 2 hours. The reaction mixture was then filtered and the filtrate chilled in ice. The precipitate which formed was collected on a suction filter. Recrystallization from ethyl acetate gave 0.8 g. of product m.p. 110°-115° C.

Workup

  1. temperatureheated on a steam bath for 2 hours
  2. filtrationThe reaction mixture was then filtered
  3. temperaturethe filtrate chilled in ice
  4. customThe precipitate which formed
  5. customwas collected on a suction
  6. filtrationfilter
  7. customRecrystallization from ethyl acetate
  8. customgave 0.8 g

Sources & evidence

ORD record
ord-925ed50f79c74740aba4aae97b2507e1
Source dataset
uspto-grants-1981_11
Patent number
US04301281

Reaction notes

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