2-Methoxyethylamine → HCID 12784102, compound

HRID 1155394Notes

Reaction equation

HRID 1155394 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH:24]=[CH2:25])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])[CH3:2].[CH3:27][O:28][CH2:29][CH2:30][NH2:31].C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH:24]=[CH2:25])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1[NH:31][CH2:30][CH2:29][O:28][CH3:27])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 80182-MethoxyethylamineHCID 10340Sodium CarbonateHCID 12784119HCID 12784119, compound

Product 1

HCID 12784102HCID 12784102, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 0.9 g. (0.0024 mole) of 8-allyl-5-chloro-7,8-dihydro-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester in 30 ml. of ethanol was added 0.17 g. (0.0024 mole) of 2-methoxyethylamine and 0.25 g. (0.0024 mole) of Na2CO3. This mixture was heated at reflux for 4 hours, then filtered and the filtrate chilled. Yellow crystals formed and were collected on a filter. Recrystallization from ethanol gave 0.5 g. of product--m.p. 155°-158° C.

Workup

  1. temperatureThis mixture was heated
  2. temperatureat reflux for 4 hours
  3. filtrationfiltered
  4. temperaturethe filtrate chilled
  5. customYellow crystals formed
  6. customwere collected on a filter
  7. customRecrystallization from ethanol
  8. customgave 0.5 g

Sources & evidence

ORD record
ord-2234eec2c43944fa972b6b5b02a052fd
Source dataset
uspto-grants-1981_11
Patent number
US04301281

Reaction notes

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