Ammonia → HCID 131712559, compound

Participants

Reaction Steps

To a mixture of 5 g dimethyl 2-(chlorosulfonyl)-1,3-benzenedicarboxylic acid and 1.4 g sodium bicarbonate in 25 ml tetrahydrofuran (dried over alumina) at 0°-5° was added, dropwise, a solution of 0.4 ml ammonia in 5 ml dry tetrahydrofuran. After stirring for 2 hours, the solution was evaporated, the resulting solid was washed with methylene chloride, then with water to give 2.4 g, m.p. 169° of dimethyl 2-(aminosulfonyl)-1,3-benzenedicarboxylic acid.

Provenance & Evidence