Ammonia → HCID 131712559, compound

HRID 1155476Notes

Reaction equation

HRID 1155476 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([S:11](Cl)(=[O:13])=[O:12])[C:5]([C:15]([OH:17])=[O:16])=[C:4]([CH3:18])[CH:3]=1.C(=O)(O)[O-].[Na+].[NH3:24]>O1CCCC1>[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([S:11]([NH2:24])(=[O:13])=[O:12])[C:5]([C:15]([OH:17])=[O:16])=[C:4]([CH3:18])[CH:3]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 516892Sodium BicarbonateHCID 131712560HCID 131712560, compound

Product 1

HCID 131712559HCID 131712559, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a mixture of 5 g dimethyl 2-(chlorosulfonyl)-1,3-benzenedicarboxylic acid and 1.4 g sodium bicarbonate in 25 ml tetrahydrofuran (dried over alumina) at 0°-5° was added, dropwise, a solution of 0.4 ml ammonia in 5 ml dry tetrahydrofuran. After stirring for 2 hours, the solution was evaporated, the resulting solid was washed with methylene chloride, then with water to give 2.4 g, m.p. 169° of dimethyl 2-(aminosulfonyl)-1,3-benzenedicarboxylic acid.

Workup

  1. additionwas added
  2. customthe solution was evaporated
  3. washthe resulting solid was washed with methylene chloride

Sources & evidence

ORD record
ord-f6c6f20812b24048bd3f70fdd8e58a2d
Source dataset
uspto-grants-1981_11
Patent number
US04302241

Reaction notes

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