Sodium borohydride → HCID 13264151, compound

HRID 1155493Notes

Reaction equation

HRID 1155493 reaction equation
[OH:1][C:2]1([C:20](OC)=[O:21])[CH2:11][C:10]2([S:15][CH2:14][CH2:13][S:12]2)[C:9]2[C:4](=[C:5]([O:18][CH3:19])[CH:6]=[CH:7][C:8]=2[O:16][CH3:17])[CH2:3]1.[BH4-].[Na+]>O1CCCC1>[OH:1][C:2]1([CH2:20][OH:21])[CH2:3][C:4]2[C:9](=[C:8]([O:16][CH3:17])[CH:7]=[CH:6][C:5]=2[O:18][CH3:19])[C:10]2([S:12][CH2:13][CH2:14][S:15]2)[CH2:11]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 13264142HCID 13264142, compound

Product 1

HCID 13264151HCID 13264151, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.0 g of methyl rac-1',2',3',4'-tetrahydro-2'-hydroxy-5',8'-dimethoxyspiro[1,3-dithiolane-2,4'-naphthalene]-2'-carboxylate, prepared as described in Example 1(iv), were dissolved in 200 ml of dry tetrahydrofuran and 2.0 g of sodium borohydride were added to the solution. The resulting mixture was stirred at room temperature under nitrogen for 20 hours. The solvent was removed by evaporation and 100 ml of 10% ammonium chloride solution were added. The mixture was extracted with three 30 ml portions of ethyl acetate. The extracts were dried and evaporated to give a colourless oil. Crystallisation of this oil from ethyl acetate/petroleum ether gave 1.6 g (87%) of rac-1',2',3',4'-tetrahydro-3'-hydroxy-3'-hydroxymethyl-5',8'-dimethoxyspiro[1,3-dithiolane-2,1'-naphthalene] of melting point 132.5°-133.5° C.

Workup

  1. customThe solvent was removed by evaporation and 100 ml of 10% ammonium chloride solution
  2. additionwere added
  3. extractionThe mixture was extracted with three 30 ml portions of ethyl acetate
  4. customThe extracts were dried
  5. customevaporated
  6. customto give a colourless oil
  7. customCrystallisation of this oil from ethyl acetate/petroleum ether

Sources & evidence

ORD record
ord-045ecbb0c2144460a533a1fd1e17e807
Source dataset
uspto-grants-1981_11
Patent number
US04302398

Reaction notes

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