HRID1155506

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID11430

Potassium Carbonate

CK2O3

HCID2826990

6,7-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium iodide

C12H16INO2

结构：CCOc1c2c(c([N+](=O)[O-])c(OCC)c1OCC)C(=O)OC2

HCID6452177

4,5,6-Triethoxy-7-nitrophthalide

C14H17NO7

PRODUCTS

生成物

结构：CCOc1c(OCC)c2c(c([N+](=O)[O-])c1OCC)C(=O)OC2C1c2cc(OC)c(OC)cc2CCN1C

HCID20560980

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

200 g (0.6 mole) of 2-methyl-6,7-dimethoxy-3,4-dihydro-isoquinolinium iodide (prepared in the same manner as the compound of Example A) 186 g of 4,5,6-triethoxy-7-nitrophthalide and 100 g of potassium carbonate are added to 1.5 l of methanol while stirring. The reaction mixture is stirred for 24 hours at a temperature below the boiling point of the solvent, and is then allowed to cool; 900 ml of water is added and the reaction solution is allowed to crystallise. The solution is filtered, rinsed with methanol, and then with water.

WORKUP

后处理

stirringThe reaction mixture is stirred for 24 hours at a temperature below the boiling point of the solvent
temperatureto cool
customto crystallise
filtrationThe solution is filtered
washrinsed with methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bc17c10b4dd148d4aaee83389a8f65d7
来源数据集: uspto-grants-1981_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04302458
来源说明: uspto-grants-1981_11

反应 SMILES

[I-].[CH3:2][N+:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([O:15][CH3:16])=[C:8]([O:13][CH3:14])[CH:9]=2)[CH:4]=1.[CH2:17]([O:19][C:20]1[C:29]([O:30][CH2:31][CH3:32])=[C:28]([O:33][CH2:34][CH3:35])[C:27]([N+:36]([O-:38])=[O:37])=[C:26]2[C:21]=1[CH2:22][O:23][C:24]2=[O:25])[CH3:18].C(=O)([O-])[O-].[K+].[K+].CO>O>[CH3:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([O:15][CH3:16])=[C:8]([O:13][CH3:14])[CH:9]=2)[CH:4]1[CH:22]1[C:21]2[C:26](=[C:27]([N+:36]([O-:38])=[O:37])[C:28]([O:33][CH2:34][CH3:35])=[C:29]([O:30][CH2:31][CH3:32])[C:20]=2[O:19][CH2:17][CH3:18])[C:24](=[O:25])[O:23]1