Hydrochloric Acid → HCID 12761757, compound

HRID 1155516Notes

Reaction equation

HRID 1155516 reaction equation
[ClH:1].[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:14][CH:15]=[CH:16][N:17]=1.C(OCC)C>CO>[ClH:1].[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:17][CH:16]=[CH:15][N:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 127617562-(1,4-BENXODIOXAN-2YL)-METHYLENE-IMIDAZOLE

Product 1

HCID 12761757HCID 12761757, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Excess 3% hydrogen chloride in methanol is added to a solution of 1.0 g. 2-(1,4-benzodioxan-2-ylmethyl)-imidazole in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized from methanol/acetone to yield 2-(1,4-benzodioxan-2-ylmethyl)imidazole hydrochloride, m.p. 221°-224° C.(d).

Workup

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-9a452e3c1a474966acdcfe0ed12263ec
Source dataset
uspto-grants-1981_11
Patent number
US04302469

Reaction notes

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