Anthranilic Acid → 2-Hydroxyquinoline
Reaction equation
[C:1](O)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[O:11]1[C:16]2C=CC=C[C:15]=2C=CN1>>[NH:4]1[C:3]2[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:1]=[CH:15][C:16]1=[O:11]Participants
3
Reactant 2
Product 1
Procedure
The required 1-H-4-quinolones for the above reactions were prepared in a similar way to that described in Example 6. The appropriate anthranilic acid was converted to the benzoxazine X which was then converted to the β-ketosulphoxide XI which then underwent ring closure to give the 1-H-quinolone XII ##STR11##
Sources & evidence
- ORD record
- ord-402680a079044796b01cb5a899e20ada
- Source dataset
- uspto-grants-1981_11
- Patent number
- US04302460
Reaction notes
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