反应详情

A mixture of 21.3 g. (0.137 mole) of 1-(2-chloro-4-pyridyl)ethanone and 0.5 g. of p-toluenesulfonic acid in 40 ml. of ethylene glycol and 300 ml. of toluene was placed in a flask fitted with a Dean-Stark trap and condenser, and was heated at reflux temperature for 16 hours. The mixture was cooled and concentrated in vacuo to give an oil which was purified by distillation under reduced pressure, 23.6 g. (86%), b.p. 65° C. (0.05 torr).

1. additionA mixture of 21.3 g
2. customfitted with a Dean-Stark trap and condenser
3. temperaturewas heated
4. temperatureat reflux temperature for 16 hours
5. temperatureThe mixture was cooled
6. concentrationconcentrated in vacuo
7. customto give an oil which
8. distillationwas purified by distillation under reduced pressure, 23.6 g