反应详情

To a mixture of 7 g. (0.1 mole) of hydroxylamine hydrochloride in 40 ml. of water and 50 ml. of 2 N sodium hydroxide was added 11.5 g. (70 mmoles) of 1-(2-ethylamino-4-pyridyl)-1-ethanone, and the resulting mixture heated to boiling. Methanol was carefully added until the mixture became homogeneous. Heating was continued until the mixture became cloudy. The mixture was cooled and the resulting precipitate filtered, washed with water and dried. Recrystallization from toluene gave 10.9 g. (87%) of the desired product, m.p. 155°-156° C.

1. additionTo a mixture of 7 g
2. temperatureHeating
3. temperatureThe mixture was cooled
4. filtrationthe resulting precipitate filtered
5. washwashed with water
6. customdried
7. customRecrystallization from toluene
8. customgave 10.9 g