Sodium Hydroxide → 1-(2-Methyl-pyridin-4-yl)-ethanone oxime

HRID 1155553Notes

Reaction equation

HRID 1155553 reaction equation
Cl.[NH2:2][OH:3].[OH-].[Na+].[CH3:6][C:7]1[CH:12]=[C:11]([C:13](=O)[CH3:14])[CH:10]=[CH:9][N:8]=1>CO>[CH3:6][C:7]1[CH:12]=[C:11]([C:13](=[N:2][OH:3])[CH3:14])[CH:10]=[CH:9][N:8]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 207050141-(2-Methylpyridin-4-yl)ethan-1-one

Product 1

HCID 1363592001-(2-Methyl-pyridin-4-yl)-ethanone oxime

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 4.03 g. (58.4 mmoles) of hydroxylamine hydrochloride in 27 ml. of a 2 N sodium hydroxide solution was added 3.95 g. (29.2 mmoles) of 2-methyl-4-acetylpyridine and the resulting mixture heated on a steam bath, methanol being added to keep the mixture homogeneous. The mixture was heated for an additional 5 minutes and was then cooled. The resulting precipitate was filtered, washed with water and dried 3.95 g. (90%), m.p. 151°-152° C.

Workup

  1. temperatureThe mixture was heated for an additional 5 minutes
  2. temperaturewas then cooled
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried 3.95 g

Sources & evidence

ORD record
ord-694a36b00d194b47b90f188a7a1c665d
Source dataset
uspto-grants-1981_11
Patent number
US04302464

Reaction notes

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