反应详情

To 4.03 g. (58.4 mmoles) of hydroxylamine hydrochloride in 27 ml. of a 2 N sodium hydroxide solution was added 3.95 g. (29.2 mmoles) of 2-methyl-4-acetylpyridine and the resulting mixture heated on a steam bath, methanol being added to keep the mixture homogeneous. The mixture was heated for an additional 5 minutes and was then cooled. The resulting precipitate was filtered, washed with water and dried 3.95 g. (90%), m.p. 151°-152° C.

1. temperatureThe mixture was heated for an additional 5 minutes
2. temperaturewas then cooled
3. filtrationThe resulting precipitate was filtered
4. washwashed with water
5. customdried 3.95 g