Water → HCID 20561342, compound

HRID 1155565Notes

Reaction equation

HRID 1155565 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:3]=1.[CH3:15][O-:16].[Na+].O>COCCOC>[NH2:1][C:2]1[CH:7]=[C:6]([O:16][CH3:15])[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 205613386-Chloro-2-(morpholin-4-yl)pyrimidin-4-amine

Product 1

HCID 20561342HCID 20561342, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
20 °C

Procedure

60.46 g of 4-amino-6-chloro-2-morpholinopyrimidine (described in Chem. Pharm. Bull. 13, 557) are suspended in 190 ml of 1,2-dimethoxyethane and to this suspension are added 35.4 g of sodium methylate. The suspension is subsequently stirred for 22 hours under reflux and then cooled to 20° C. After addition of 180 ml of water the precipitated product is collected by suction and dried in vacuo at 80° C., affording 39.1 g (66% of theory) of 4-amino-6-methoxy-2-morpholinopyrimidine with a melting point of 162° C.-164° C.

Workup

  1. temperatureunder reflux
  2. customis collected by suction
  3. customdried in vacuo at 80° C.

Sources & evidence

ORD record
ord-d14de94fab0a4e659ee21e2c15fa47ac
Source dataset
uspto-grants-1981_11
Patent number
US04302586

Reaction notes

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