Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 6-Chloro-2-(morpholin-4-yl)pyrimidin-4-amine | HCID 20561338 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 20561342 | HCID 20561342 | 66% |
Reaction Steps
60.46 g of 4-amino-6-chloro-2-morpholinopyrimidine (described in Chem. Pharm. Bull. 13, 557) are suspended in 190 ml of 1,2-dimethoxyethane and to this suspension are added 35.4 g of sodium methylate. The suspension is subsequently stirred for 22 hours under reflux and then cooled to 20° C. After addition of 180 ml of water the precipitated product is collected by suction and dried in vacuo at 80° C., affording 39.1 g (66% of theory) of 4-amino-6-methoxy-2-morpholinopyrimidine with a melting point of 162° C.-164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04302586 |
|---|
| Source dataset | uspto-grants-1981_11 |
|---|
| ORD ID | ord-d14de94fab0a4e659ee21e2c15fa47ac |
|---|
| Source note | uspto-grants-1981_11 |
|---|
