Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Fuming sulfuric acid | HCID 24681 | — |
| Reactant | 3-Trifluoromethylisobutyranilide | HCID 137264 | — |
| Solvent | Water | HCID 962 | — |
| Product | Flutamide | HCID 3397 | — |
Reaction Steps
Add portion-wise 57.5 g. of m-trifluoromethyl isobutyranilide to 260 ml. of 15-18% oleum while maintaining the internal temperature at about 5° C. To this mixture add drop-wise 20 g. of 90% nitric acid with stirring. Stir at about 5° C. for 2 hours and pour into about 11/2 liters of ice and water with stirring. Collect the 3'-trifluoromethyl-4'-nitro-isobutyranilide by filtration and wash with water until substantially free of excess acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04302599 |
|---|
| Source dataset | uspto-grants-1981_11 |
|---|
| ORD ID | ord-3bb1905416d647b5a51cf2e60bb04d16 |
|---|
| Source note | uspto-grants-1981_11 |
|---|
