反应详情

温度

5 °C

Add portion-wise 57.5 g. of m-trifluoromethyl isobutyranilide to 260 ml. of 15-18% oleum while maintaining the internal temperature at about 5° C. To this mixture add drop-wise 20 g. of 90% nitric acid with stirring. Stir at about 5° C. for 2 hours and pour into about 11/2 liters of ice and water with stirring. Collect the 3'-trifluoromethyl-4'-nitro-isobutyranilide by filtration and wash with water until substantially free of excess acid.

1. additionAdd portion-wise 57.5 g
2. additionTo this mixture add drop-wise 20 g
3. stirringwith stirring
4. customCollect the 3'-trifluoromethyl-4'-nitro-isobutyranilide
5. filtrationby filtration
6. washwash with water until substantially free of excess acid