Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Fuming sulfuric acid | HCID 24681 | — |
| Reactant | HCID 838176 | HCID 838176 | — |
| Product | HCID 20561423 | HCID 20561423 | — |
Reaction Steps
Add portion-wise 16.4 g. of m-acetyl-isobutyranilide to a solution of 44 milliliters of concentrated sulfuric acid and 62 milliliters of oleum (30-33%) while maintaining the internal temperature at 0°-5° C. Cool the mixture to -8° C. and add drop-wise 65 milliliters of 90% nitric acid. Stir the reaction mixture at 0°-5° C. for an additional 40 minutes and precipitate the product as described in Example 1 to obtain 3'-acetyl-4'-nitro-isobutyranilide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04302599 |
|---|
| Source dataset | uspto-grants-1981_11 |
|---|
| ORD ID | ord-d59a139936424594800d1084e71c2102 |
|---|
| Source note | uspto-grants-1981_11 |
|---|
