Nitric Acid → HCID 20561423, compound

HRID 1155581Notes

Reaction equation

HRID 1155581 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:13]=[CH:14][CH:15]=1)[NH:7][C:8](=[O:12])[CH:9]([CH3:11])[CH3:10])(=[O:3])[CH3:2].S(=O)(=O)(O)O.OS(O)(=O)=O.O=S(=O)=O.[N+:30]([O-])([OH:32])=[O:31]>>[C:1]([C:4]1[CH:5]=[C:6]([CH:13]=[CH:14][C:15]=1[N+:30]([O-:32])=[O:31])[NH:7][C:8](=[O:12])[CH:9]([CH3:11])[CH3:10])(=[O:3])[CH3:2]

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 24681Fuming sulfuric acidHCID 838176HCID 838176, compound

Product 1

HCID 20561423HCID 20561423, compound

Conditions

Temperature
-8 °C

Procedure

Add portion-wise 16.4 g. of m-acetyl-isobutyranilide to a solution of 44 milliliters of concentrated sulfuric acid and 62 milliliters of oleum (30-33%) while maintaining the internal temperature at 0°-5° C. Cool the mixture to -8° C. and add drop-wise 65 milliliters of 90% nitric acid. Stir the reaction mixture at 0°-5° C. for an additional 40 minutes and precipitate the product as described in Example 1 to obtain 3'-acetyl-4'-nitro-isobutyranilide.

Workup

  1. additionAdd portion-wise 16.4 g
  2. additionadd
  3. customprecipitate the product

Sources & evidence

ORD record
ord-d59a139936424594800d1084e71c2102
Source dataset
uspto-grants-1981_11
Patent number
US04302599

Reaction notes

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