Ammonium Hydroxide → HCID 20537368, compound

HRID 1155656Notes

Reaction equation

HRID 1155656 reaction equation
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH2:12][N:13]2[CH2:24][CH2:23][C:16]3([O:21][CH2:20][C:19](=[O:22])[NH:18][CH2:17]3)[CH2:15][CH2:14]2)=[CH:3]1.[OH-].[NH4+]>O>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH2:12][N:13]2[CH2:24][CH2:23][C:16]3([O:21][CH2:20][C:19](=[O:22])[NH:18][CH2:17]3)[CH2:15][CH2:14]2)=[CH:3]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 20537375HCID 20537375, compound

Product 1

HCID 20537368HCID 20537368, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3.5 g of 9-[2-(3-indolyl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride salt in water (50 ml) was adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride was evaporated to afford 3 g of 9-[2-(3-indolyl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one as the free base, mp 48°-50° C.

Workup

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride was evaporated

Sources & evidence

ORD record
ord-0c83fe338f394c5fa220b2de7b3e8731
Source dataset
uspto-grants-1982_06
Patent number
US04332804

Reaction notes

Loading…