4-Toluenesulfonyl chloride → HCID 178500029, compound

HRID 1155676Notes

Reaction equation

HRID 1155676 reaction equation
[CH3:1][O:2][C:3](=[O:41])[C@:4]([C:22]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([CH2:13][C:14]1[N:18]=[C:17]([CH:19]([OH:21])[CH3:20])[NH:16][CH:15]=1)[N:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[S:42](Cl)([C:45]1[CH:51]=[CH:50][C:48]([CH3:49])=[CH:47][CH:46]=1)(=[O:44])=[O:43]>N1C=CC=CC=1>[CH3:1][O:2][C:3](=[O:41])[C@:4]([C:22]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)([CH2:13][C:14]1[N:18]=[C:17]([CH:19]([O:21][S:42]([C:45]2[CH:51]=[CH:50][C:48]([CH3:49])=[CH:47][CH:46]=2)(=[O:44])=[O:43])[CH3:20])[NH:16][CH:15]=1)[N:5]=[CH:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 178500028HCID 178500028, compound

Product 1

HCID 178500029HCID 178500029, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To the solution of compound 2·III from Step C is added 0.5 ml of pyridine and then 190.5 mg (1 mmole) of tosyl chloride. After 30 minutes at 25° C. the solution is washed three times with water, once with brine, and dried with K2CO3 and filtered. The filtrate is used directly in the next step.

Workup

  1. washAfter 30 minutes at 25° C. the solution is washed three times with water
  2. dry with materialonce with brine, and dried with K2CO3
  3. filtrationfiltered

Sources & evidence

ORD record
ord-b032f47edab24c3eaddfbae328ff27ac
Source dataset
uspto-grants-1982_06
Patent number
US04332813

Reaction notes

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