Trifluoroacetic acid → HCID 22820346, compound

Participants

Reaction Steps

Crude II from Step B is taken up in 2 ml anisole and then treated at 0° C. for 11 minutes with 10 ml of TFA. The TFA and anisole are pumped off at 0.1 Torr at 30° C. and the residue partitioned between chloroform and aqueous 1 N HCl. The aqueous layer is made to pH 9.0 with NaOH and extracted with CH2Cl2, providing a solution of compound 3·III.

Provenance & Evidence