Trifluoroacetic acid → HCID 22820346, compound

HRID 1155678Notes

Reaction equation

HRID 1155678 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:13][S:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[NH:5]C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C1(OC)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:13][S:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[NH2:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 22820341HCID 22820341, compound

Product 1

HCID 22820346HCID 22820346, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent2×

Procedure

Crude II from Step B is taken up in 2 ml anisole and then treated at 0° C. for 11 minutes with 10 ml of TFA. The TFA and anisole are pumped off at 0.1 Torr at 30° C. and the residue partitioned between chloroform and aqueous 1 N HCl. The aqueous layer is made to pH 9.0 with NaOH and extracted with CH2Cl2, providing a solution of compound 3·III.

Workup

  1. customare pumped off at 0.1 Torr at 30° C.
  2. customthe residue partitioned between chloroform and aqueous 1 N HCl
  3. extractionextracted with CH2Cl2
  4. customproviding a solution of compound 3·III

Sources & evidence

ORD record
ord-0113189ea0074de69cc7b61720183f2f
Source dataset
uspto-grants-1982_06
Patent number
US04332813

Reaction notes

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