Methane → HCID 20537466, compound

Participants

Reaction Steps

50 g of hydrochloride of Step A in 1.5 liters of methanol was hydrogenated at 40° C. in the presence of 15 g of palladized active charcoal. The mixture was then cooled and the catalyst was filtered off. The filtrate was distilled to dryness under vacuum to obtain 37 g of 3-(1-methyl-1H-indole-4-yl)-3-piperidinol hydrochloride with an Rf=0.3 [Support: silica--Eluant: chloroform-methanol-triethylamine (6:3:1)].

Provenance & Evidence