Methane → HCID 20537466, compound

HRID 1155693Notes

Reaction equation

HRID 1155693 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2C.[CH4:12].[CH3:13][OH:14]>>[ClH:1].[CH3:12][N:6]1[C:7]2[C:3](=[C:2]([C:13]3([OH:14])[CH2:3][CH2:4][CH2:5][NH:6][CH2:7]3)[CH:10]=[CH:9][CH:8]=2)[CH:4]=[CH:5]1

Participants

4

Reactant 3

HCID 297MethaneHCID 887MethanolHCID 130487594-Chloro-1-methyl-1H-indole

Product 1

HCID 20537466HCID 20537466, compound

Procedure

50 g of hydrochloride of Step A in 1.5 liters of methanol was hydrogenated at 40° C. in the presence of 15 g of palladized active charcoal. The mixture was then cooled and the catalyst was filtered off. The filtrate was distilled to dryness under vacuum to obtain 37 g of 3-(1-methyl-1H-indole-4-yl)-3-piperidinol hydrochloride with an Rf=0.3 [Support: silica--Eluant: chloroform-methanol-triethylamine (6:3:1)].

Workup

  1. temperatureThe mixture was then cooled
  2. filtrationthe catalyst was filtered off
  3. distillationThe filtrate was distilled to dryness under vacuum

Sources & evidence

ORD record
ord-c533caf766f54e8197a6a48d8816c66b
Source dataset
uspto-grants-1982_06
Patent number
US04332808

Reaction notes

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