1,1'-Carbonyldiimidazole → HCID 178492685, compound

HRID 1155700Notes

Reaction equation

HRID 1155700 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)[N:6]=[C:5]([C:19]([OH:21])=O)[CH:4]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:34][C:35]1[NH:39][N:38]=[N:37][N:36]=1>>[NH:36]1[C:35]([NH:34][C:19]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([C:9]3[CH:10]=[CH:11][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:13][CH:14]=3)[N:6]=2)=[O:21])=[N:39][N:38]=[N:37]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 12811151HCID 12811151, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178492685HCID 178492685, compoundYield 84.5%

Procedure

In the same manner as described in Example 1-(1), 4-methoxy-6-(4-acetylaminophenyl)-2-pyridinecarboxylic acid (0.46 g), carbonyldiimidazole (0.29 g) and 5-aminotetrazole (0.15 g) are reacted to give N-(5-tetrazolyl)-4-methoxy-6-(4-acetylaminophenyl)-2-pyridinecarboxamide (0.48 g). M.P. 286°-288° C. (decomp.) (recrystallized from dimethylformamide-ethanol)

Sources & evidence

ORD record
ord-5360a141b4384d368ba1a05a5165c3c3
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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