1,1'-Carbonyldiimidazole → HCID 178474082, compound

HRID 1155703Notes

Reaction equation

HRID 1155703 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:17])[CH3:16])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:18]([OH:20])=O)[CH:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:33][C:34]1[NH:38][N:37]=[N:36][N:35]=1>>[NH:35]1[C:34]([NH:33][C:18]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]3[CH:9]=[CH:10][C:11]([NH:14][C:15](=[O:17])[CH3:16])=[CH:12][CH:13]=3)[N:5]=2)=[O:20])=[N:38][N:37]=[N:36]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 12811141HCID 12811141, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178474082HCID 178474082, compoundYield 72.1%

Procedure

In the same manner as described in Example 1-(1), 4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxylic acid (1.0 g), carbonyldiimidazole (0.72 g) and 5-aminotetrazole (0.38 g) are reacted to give N-(5-tetrazolyl)-4-methyl-6-(4-acetylaminophenyl)-2-pyridinecarboxamide (0.9 g). M.P. 309°-310° C. (decomp.) (wetted at about 290° C.) (recrystallized from dimethylformamide-ethanol)

Sources & evidence

ORD record
ord-67284dbaefe6458bbfc8be509ccc0213
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

Loading…