Phosphorus oxychloride → HCID 12862371, compound

HRID 1155883Notes

Reaction equation

HRID 1155883 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([NH2:14])=O)[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[S:15][C:16]([CH2:18][CH2:19][CH3:20])=[CH:17][C:3]1=2.P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]#[N:14])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[S:15][C:16]([CH2:18][CH2:19][CH3:20])=[CH:17][C:3]1=2

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 12862364HCID 12862364, compound

Product 1

HCID 12862371HCID 12862371, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

From 2.0 g (0.007 mol) of 4-oxo-2-propyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide (Example 23), 30 ml of phosphorus oxychloride and 30 ml of chloroform, following the procedure of Example 27, there is obtained 1.8 g of 4-oxo-2-propyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carbonitrile; mp 217°-218° C. after recrystallization from glacial acetic acid.

Sources & evidence

ORD record
ord-cc05d5bf5b4146f2a1135ada8c595174
Source dataset
uspto-grants-1982_06
Patent number
US04332947

Reaction notes

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