Chlorosuccinimide → HCID 12953049, compound

HRID 1155906Notes

Reaction equation

HRID 1155906 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][S:18][CH2:19][C:3]1=2.ClN1C(=O)CCC1=O>N1C=CC=CC=1>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2=[CH:17][S:18][CH:19]=[C:3]12

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12953041HCID 12953041, compound

Product 1

HCID 12953049HCID 12953049, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno[3,4-d]pyrimidine-7-carboxylate (2.0 g., 0.0072 mole) and N-chlorosuccinimide (0.97 g., 0.0072 mol) in pyridine (20 ml) is heated on a steam bath for 18 minutes. The reaction mixture is cooled and poured into a large volume of ice water. The precipitate is filtered, washed with water and dried. Recrystallization from ethanol gives the product (1.1 g.), mp 175°-176° C.

Workup

  1. temperatureis heated on a steam bath for 18 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitate is filtered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from ethanol
  7. customgives the product (1.1 g.), mp 175°-176° C.

Sources & evidence

ORD record
ord-46991f5070d94997aaecfc5cfcbf31fa
Source dataset
uspto-grants-1982_06
Patent number
US04332947

Reaction notes

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