HCID 12953045, compound → HCID 12953046, compound

HRID 1155930Notes

Reaction equation

HRID 1155930 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14]CC)=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][CH2:18][S:19][C:3]1=2>Cl>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][CH2:18][S:19][C:3]1=2

Participants

3

Reactant 1

HCID 12953045HCID 12953045, compound

Product 1

HCID 12953046HCID 12953046, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxylate (5.0 g., 0.018 mol) in 2N hydrochloric acid (60 ml) is refluxed for 3 hours. The reaction mixture is cooled in an ice-bath. The precipitate is filtered, washed with water, with acetone and dried to give the product (3.5 g.), mp 325° C. (dec).

Workup

  1. temperatureis refluxed for 3 hours
  2. temperatureThe reaction mixture is cooled in an ice-bath
  3. filtrationThe precipitate is filtered
  4. washwashed with water, with acetone
  5. customdried
  6. customto give the product (3.5 g.), mp 325° C. (dec)

Sources & evidence

ORD record
ord-9fd960d867f8491c8e0bca2f7a6ad022
Source dataset
uspto-grants-1982_06
Patent number
US04332947

Reaction notes

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