HCID 20536176, compound → HCID 20536174, compound

HRID 1155937Notes

Reaction equation

HRID 1155937 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=1[NH:15][C:16](=[O:18])[CH3:17]>C(O)C.[Pd]>[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=1[NH:15][C:16](=[O:18])[CH3:17]

Participants

4

Reactant 1

HCID 20536176HCID 20536176, compound

Product 1

HCID 20536174HCID 20536174, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.026 mol (6.5 g) of 2-acetylamino-4-nitrophenyl γ-aminopropyl ether in 32 cm3 of absolute ethanol is reduced on a 10% strength Pd/C catalyst under a hydrogen pressure of 20 bars, at 80° C., for one hour. After filtration and after cooling the filtrate with a solid carbon dioxide bath, the expected product precipitates. The product is filtered off and dried in vacuo over P2O5. It melts at 102°-106° C.

Workup

  1. filtrationAfter filtration
  2. temperatureafter cooling the filtrate with a solid carbon dioxide bath
  3. customthe expected product precipitates
  4. filtrationThe product is filtered off
  5. dry with materialdried in vacuo over P2O5

Sources & evidence

ORD record
ord-b3dc09fe9f374c728905666982bed807
Source dataset
uspto-grants-1982_06
Patent number
US04333730

Reaction notes

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