Ethanol → N-[(4-Methylquinazolin-2-yl)aminocarbonyl]-2-carboxybenzenesulfonamide

Participants

Reaction Steps

A mixture containing 5 g of methyl 2-[[(4-methylquinazolin-2-yl)aminocarbonyl]aminosulfonyl]benzoate, 20 ml of ethanol, 2.5 ml of water and 2.5 g of potassium hydroxide is stirred at ambient temperature and pressure for 18 hours. The mixture is then diluted with water and 20 ml of concentrted hydrochloric acid added with stirring. The resulting precipitate is filtered, washed with water and dried.

Provenance & Evidence