Ethanol → N-[(4-Methylquinazolin-2-yl)aminocarbonyl]-2-carboxybenzenesulfonamide

HRID 1155943Notes

Reaction equation

HRID 1155943 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([NH:12][C:13]([NH:15][S:16]([C:19]2[CH:28]=[CH:27][CH:26]=[CH:25][C:20]=2[C:21]([O:23]C)=[O:22])(=[O:18])=[O:17])=[O:14])[N:3]=1.C(O)C.[OH-].[K+]>O.Cl>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([NH:12][C:13]([NH:15][S:16]([C:19]2[CH:28]=[CH:27][CH:26]=[CH:25][C:20]=2[C:21]([OH:23])=[O:22])(=[O:17])=[O:18])=[O:14])[N:3]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 14774717Methyl 2-[[(4-methylquinazolin-2-yl)aminocarbonyl]aminosulfonyl]benzoate

Product 1

HCID 20536263N-[(4-Methylquinazolin-2-yl)aminocarbonyl]-2-carboxybenzenesulfonamide

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent2×

Procedure

A mixture containing 5 g of methyl 2-[[(4-methylquinazolin-2-yl)aminocarbonyl]aminosulfonyl]benzoate, 20 ml of ethanol, 2.5 ml of water and 2.5 g of potassium hydroxide is stirred at ambient temperature and pressure for 18 hours. The mixture is then diluted with water and 20 ml of concentrted hydrochloric acid added with stirring. The resulting precipitate is filtered, washed with water and dried.

Workup

  1. additionadded
  2. stirringwith stirring
  3. filtrationThe resulting precipitate is filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-97ea330e2d1d4686a2d0a0d92271ab33
Source dataset
uspto-grants-1982_06
Patent number
US04333760

Reaction notes

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