反应详情

Propionyl chloride (5.1 g) was added dropwise to 2-(2-hydroxy-5-cyanophenyl)-2-methyl-1-propanol (5 g) prepared as in Example 26 and triethylamine (5.5 g) in diethyl ether (50 ml) with stirring and cooling. After stirring for 3 hours at room temperature, the mixture was washed twice with water, dried over magnesium sulphate and run down, giving 6.5 g of crude product. After filtration through alumina in toluene, 5.3 g of title product were obtained as a viscous oil.

1. temperaturecooling
2. stirringAfter stirring for 3 hours at room temperature
3. washthe mixture was washed twice with water
4. dry with materialdried over magnesium sulphate
5. customgiving 6.5 g of crude product
6. filtrationAfter filtration through alumina in toluene