反应详情

Acetyl chloride (3.5 g) in diethyl ether (10 ml) was added portionwise with swirling and ice cooling (5°-10° C.) to 2-(5-cyano-2-hydroxyphenyl)-2-methyl-1-propanol (3.8 g) prepared as in Example 26 and triethylamine (4.6 g) in diethyl ether (40 ml). The mixture was allowed to warm to room temperature, and was left for three hours before washing with water twice, drying over magnesium sulphate, and running down. The crude product (4 g) was dissolved in toluene and filtered through a bed of aluminium oxide. Removal of the toluene left the title product (2.3 g) as a colourless oil.

1. washbefore washing with water twice
2. dry with materialdrying over magnesium sulphate
3. dissolutionThe crude product (4 g) was dissolved in toluene
4. filtrationfiltered through a bed of aluminium oxide
5. customRemoval of the toluene
6. waitleft the title product (2.3 g) as a colourless oil