Hydrochloric Acid → HCID 13036368, compound

HRID 1156009Notes

Reaction equation

HRID 1156009 reaction equation
[N:1]1[C:5]2=[CH:6][CH:7]=[CH:8][CH:9]=[CH:10][C:4]2=[N:3][C:2]=1[N:11]1[CH2:16][CH2:15][N:14](C=O)[CH2:13][CH2:12]1.Cl>C(O)C>[N:11]1([C:2]2[N:3]=[C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=[C:5]3[N:1]=2)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13036367HCID 13036367, compound

Product 1

HCID 13036368HCID 13036368, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-(cycloheptimidazol-2-yl)-1-piperazinecarboxaldehyde (38 g) in a solution of 500 ml of 2 N hydrogen chloride in ethanol was refluxed for 6 hr and allowed to stand at room temperature for 18 hr. The precipitate was collected and dried to give the title compound as the hydrochloride salt (31 g): mp>280° C. and nmr (DMSO-d6) δ 3.37 (t, 4H), 4.3 (t, 4H), 8.4 (m, 5H) and 10.0 (s, 2H).

Workup

  1. customThe precipitate was collected
  2. customdried

Sources & evidence

ORD record
ord-c4dccf51bd27432c8ac831b5746107f6
Source dataset
uspto-grants-1982_06
Patent number
US04333937

Reaction notes

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