HCID 13036367, compound → HCID 13036372, compound

HRID 1156010Notes

Reaction equation

HRID 1156010 reaction equation
N1C2=CC=CC=CC2=NC=1N1CCN(C=O)CC1.[Cl:19][C:20]1[CH:21]=[CH:22][C:23]2[C:24](=[CH:36][CH:37]=1)[N:25]=[C:26]([N:28]1[CH2:33][CH2:32][N:31](C=O)[CH2:30][CH2:29]1)[N:27]=2>>[ClH:19].[Cl:19][C:20]1[CH:21]=[CH:22][C:23]2[C:24](=[CH:36][CH:37]=1)[N:25]=[C:26]([N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1)[N:27]=2

Participants

3

Reactant 2

HCID 13036367HCID 13036367, compoundHCID 13036370HCID 13036370, compound

Product 1

HCID 13036372HCID 13036372, compound

Procedure

In the same manner, but replacing 4-(cycloheptimidazol-2-yl)-1-piperazinecarboxaldehyde with an equivalent amount of 4-(6-chloro-cycloheptimidazol-2-yl)-1-piperazinecarboxaldehyde, there was obtained 6-chloro-2-(1-piperazinyl)cycloheptimidazole hydrochloride: mp 210° C. (crystallized from methanol-acetone) and nmr (DMSO-d6) δ 3.30 (4H), 4.07 (4H), 7.73 (d, 2H), 8.27 (d, 2H) and 9.65 (1H).

Sources & evidence

ORD record
ord-a93d79edc1d24d6c898ecd962512f272
Source dataset
uspto-grants-1982_06
Patent number
US04333937

Reaction notes

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