2-Chloro-4-aminopyrimidine → HCID 13036388, compound

HRID 1156012Notes

Reaction equation

HRID 1156012 reaction equation
[N:1]1([C:7]2[N:8]=[C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=[C:10]3[N:11]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:18]1[N:23]=[C:22]([NH2:24])[CH:21]=[CH:20][N:19]=1>>[N:11]1[C:10]2=[CH:12][CH:13]=[CH:14][CH:15]=[CH:16][C:9]2=[N:8][C:7]=1[N:1]1[CH2:6][CH2:5][N:4]([C:18]2[N:23]=[C:22]([NH2:24])[CH:21]=[CH:20][N:19]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 3457522-Chloro-4-aminopyrimidineHCID 13036368HCID 13036368, compound

Product 1

HCID 13036388HCID 13036388, compound

Procedure

Similarly, by condensing 2-(1-piperazinyl)cycloheptimidazole with 2-chloro-4-aminopyrimidine, there was obtained 2-[4-(2-cycloheptimidazolyl)-1-piperazinyl]-4-pyrimidinamine (I: R1, R2, R4 and R5 =H; R3 =2-cycloheptimidazolyl; and n=1) as the di-(Z)-2-butenedioate salt: mp 205°-208° C. (crystallized from methanol-diethyl ether); and Anal. Calcd for C16H17N7.2C4H4O4 : C, 53.43% H, 4.63% N, 18.18% and Found: C, 53.66% H, 4.81% N, 18.34%.

Sources & evidence

ORD record
ord-4556f0ec36664160a6aff6e82e10ceb2
Source dataset
uspto-grants-1982_06
Patent number
US04333937

Reaction notes

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