2-Chloro-4-aminopyrimidine → HCID 13036388, compound

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Reaction Steps

Similarly, by condensing 2-(1-piperazinyl)cycloheptimidazole with 2-chloro-4-aminopyrimidine, there was obtained 2-[4-(2-cycloheptimidazolyl)-1-piperazinyl]-4-pyrimidinamine (I: R1, R2, R4 and R5 =H; R3 =2-cycloheptimidazolyl; and n=1) as the di-(Z)-2-butenedioate salt: mp 205°-208° C. (crystallized from methanol-diethyl ether); and Anal. Calcd for C16H17N7.2C4H4O4 : C, 53.43% H, 4.63% N, 18.18% and Found: C, 53.66% H, 4.81% N, 18.34%.

Provenance & Evidence