反应详情

A solution of 0.85 g of acetyl chloride in 5 ml of benzene is added dropwise to a solution of 2.8 g of 4-(4-aminophenoxy)-1-methyl-4-phenylpiperidine and 1.1 g of triethylamine in 10 ml of benzene. After stirring the mixture at room temperature for 6 hours, it is concentrated; the resulting residue is taken up with 30 ml each of water and diethyl ether; the obtained mixture is shaken thoroughly, and the organic phase is separated off, dried over sodium sulfate and concentrated. 2.8 g of the title compound remain as a viscous yellow oil which crystallizes (m.p. 143° to 144° C.) from diethylether after standing for several days.

1. concentrationit is concentrated
2. stirringthe obtained mixture is shaken thoroughly
3. customthe organic phase is separated off
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customcrystallizes (m.p. 143° to 144° C.) from diethylether
7. waitafter standing for several days