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Hydrochloric Acid → 2-Hydroxy-1-naphthaldehyde-o-aminobenzoyl hydrazone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Hexamethylenetetramine | HCID 4101 | — |
| 反応物 | Methyl Anthranilate | HCID 8635 | — |
| 反応物 | 2-Naphthol | HCID 8663 | — |
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 2-Hydroxy-1-naphthaldehyde | HCID 12819 | — |
| 反応物 | Benzoic acid, 2-amino-, hydrazide | HCID 94728 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Hydroxy-1-naphthaldehyde-o-aminobenzoyl hydrazone | HCID 3084951 | 80% |
反応手順
In reaction (1), o-aminobenzhydrazide in 70% yield is prepared by reacting the methyl ester of o-amino benzoic acid (methyl anthranilate) with 64% aqueous hydrazine. Equation (2) illustrates the preparation of 2-hydroxy-1-naphthaladehyde from beta-naphthol, paraformaldehyde, hexamethylene tetramine, acetic acid and hydrochloric acid. o-Aminobenzhydrazide and 2-hydroxy-1-naphthaldehyde are reacted, in Equation (3), to produce the preferred hydrazone, 2-hydroxy-1-naphthaldehyde-o-aminobenzoyl hydrazone in 80-90% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04334015 |
| 出典データセット | uspto-grants-1982_06 |
| ORD ID | ord-c6aac1509044478383a173aad1c1e336 |
| 出典メモ | uspto-grants-1982_06 |