反应详情

A mixture of 8.3 g. of methyl 4-amino-2-fluorobenzoate, 15.0 g of hexadecylbromide, 6.8 g of anhydrous potassium carbonate and 50 ml of hexamethylphosphoramide is heated to 135° for 20 hours. Upon cooling, dilution with water and extraction with ether, the orange colored ethereal extract is washed with water, dried and evaporated to yield an off-white solid. Recrystallization of this material from hexane affords methyl-2-fluoro-4-(hexadecylamino)benzoate.

1. additionA mixture of 8.3 g
2. temperatureUpon cooling
3. extractiondilution with water and extraction with ether
4. extractionthe orange colored ethereal extract
5. washis washed with water
6. customdried
7. customevaporated
8. customto yield an off-white solid
9. customRecrystallization of this material from hexane