Hydrochloric Acid → HCID 13036885, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2.72 g. of 7-aminocephalosporanic acid, 1.82 g. of 4-amino-5-(1-pyrazolyl)-4H-1,2,4-triazole-3-thiol and 1.68 g. of sodium bicarbonate in 75 ml. of pH 6.4 phosphate buffer is stirred and heated at 60° C. for 7 hours. The resulting solution is cooled, acidified to pH 3 with 4 N hydrochloric acid and the precipitate is collected by filtration and dried, giving 2.6 g. of the desired product, I.R. 5.60μ (β-lactam carbonyl).

Provenance & Evidence