Hydrochloric Acid → HCID 13036885, compound

HRID 1156145Notes

Reaction equation

HRID 1156145 reaction equation
CC(O[CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.[NH2:19][N:20]1[C:24]([N:25]2[CH:29]=[CH:28][CH:27]=[N:26]2)=[N:23][N:22]=[C:21]1[SH:30].C(=O)(O)[O-].[Na+].P([O-])([O-])([O-])=O.Cl>>[NH2:13][CH:10]1[C:11](=[O:12])[N:8]2[CH:9]1[S:14][CH2:15][C:6]([CH2:5][S:30][C:21]1[N:20]([NH2:19])[C:24]([N:25]3[CH:29]=[CH:28][CH:27]=[N:26]3)=[N:23][N:22]=1)=[C:7]2[C:16]([OH:18])=[O:17]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1061PhosphateHCID 4413287-Aminocephalosporanic acidHCID 516892Sodium BicarbonateHCID 178514282HCID 178514282, compound

Product 1

HCID 13036885HCID 13036885, compound

Conditions

Temperature
60 °C

Procedure

A solution of 2.72 g. of 7-aminocephalosporanic acid, 1.82 g. of 4-amino-5-(1-pyrazolyl)-4H-1,2,4-triazole-3-thiol and 1.68 g. of sodium bicarbonate in 75 ml. of pH 6.4 phosphate buffer is stirred and heated at 60° C. for 7 hours. The resulting solution is cooled, acidified to pH 3 with 4 N hydrochloric acid and the precipitate is collected by filtration and dried, giving 2.6 g. of the desired product, I.R. 5.60μ (β-lactam carbonyl).

Workup

  1. temperatureThe resulting solution is cooled
  2. filtrationthe precipitate is collected by filtration
  3. customdried
  4. customgiving 2.6 g

Sources & evidence

ORD record
ord-a9b32ad9f13d4876a3e630616594917c
Source dataset
uspto-grants-1982_06
Patent number
US04334062

Reaction notes

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